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Endocrine · Same-week appointments · NICE NG145

Hypothyroidism & thyroid disease.

Thyroid disease is one of the most common medical conditions in the UK and one of the most commonly under-diagnosed. NHS thyroid testing is often limited to TSH alone, and "normal" reference ranges can miss patients who are genuinely symptomatic. Our approach is comprehensive testing, careful interpretation, and individualised treatment.

Appointment waitTypically 1–7 days
IncludesComprehensive thyroid panel
ApproachNICE NG145 aligned

Educational information — not a substitute for clinical assessment

This page describes thyroid disease in general terms to help you decide whether assessment may be helpful. It is not a diagnostic tool. If you recognise yourself in what follows, please book a consultation.

About the thyroid

The thyroid is a butterfly-shaped gland in the front of the neck that produces hormones (T4 and T3) that regulate metabolism, energy, body temperature, growth, brain function, and many other processes. When the thyroid produces too little hormone (hypothyroidism) or too much (hyperthyroidism), symptoms can affect almost any body system.

Thyroid hormones are produced under the control of TSH (thyroid stimulating hormone) from the pituitary gland. When thyroid hormone levels fall, TSH rises to compensate — making TSH the most sensitive single marker of thyroid function.

~5%

of UK adults have hypothyroidism; many remain undiagnosed. Women are affected 5–10 times more often than men. Diagnosis is straightforward when you test properly.

Hypothyroidism (underactive thyroid)

The most common thyroid problem. Symptoms develop gradually and are often attributed to ageing, stress, or "just being tired":

Common symptoms

  • Persistent tiredness, fatigue
  • Weight gain or difficulty losing weight
  • Cold intolerance — feeling cold when others don’t
  • Brain fog, slowed thinking, memory issues
  • Low mood, sometimes depression
  • Constipation
  • Dry skin, brittle nails, hair thinning
  • Muscle aches, joint stiffness
  • Heavy or irregular periods (women)
  • Reduced libido
  • Hoarse voice
  • Slow pulse
  • Puffy face, swelling around eyes

Causes

  • Autoimmune (Hashimoto’s thyroiditis) — the commonest cause in the UK
  • Iodine deficiency (rare in UK)
  • Previous thyroid surgery or radioactive iodine treatment
  • Medications (lithium, amiodarone, some others)
  • Post-pregnancy thyroid changes (postpartum thyroiditis)
  • Pituitary or hypothalamic problems (less common)

Subclinical hypothyroidism

TSH mildly elevated with normal T4 levels. May or may not need treatment — depends on symptoms, antibody status, age, and TSH level. Subject to careful clinical judgement; not always treated routinely.

Hyperthyroidism (overactive thyroid)

Less common than hypothyroidism but important to recognise:

Symptoms

  • Weight loss despite eating normally or more
  • Heat intolerance, sweating
  • Rapid heart rate, palpitations
  • Anxiety, irritability, restlessness
  • Difficulty sleeping
  • Tremor (especially hands)
  • Diarrhoea or more frequent bowel motions
  • Light or absent periods (women)
  • Eye changes (bulging, irritation — particularly with Graves’)
  • Goitre (visibly enlarged thyroid)
  • Muscle weakness

Causes

  • Graves’ disease — autoimmune cause, the commonest
  • Toxic nodular goitre
  • Toxic single nodule
  • Thyroiditis (inflammation)
  • Excessive thyroid hormone medication

Hyperthyroidism needs specialist endocrinology assessment for diagnosis and treatment planning. Untreated hyperthyroidism can cause significant cardiovascular complications.

Autoimmune thyroid disease

The two main autoimmune thyroid conditions:

  • Hashimoto’s thyroiditis — the immune system gradually destroys thyroid tissue, causing hypothyroidism. Detected by anti-TPO and anti-thyroglobulin antibodies.
  • Graves’ disease — antibodies stimulate the thyroid to over-produce. Detected by TSH receptor antibodies.

Autoimmune thyroid disease commonly co-exists with other autoimmune conditions (coeliac, type 1 diabetes, vitiligo, pernicious anaemia, others). We screen accordingly.

Thyroid nodules

Lumps within the thyroid gland. Very common (around half of adults if examined carefully or scanned). The vast majority are benign, but the small minority that are cancerous warrant identification and management. Assessment includes:

  • Examination and history
  • Thyroid function tests
  • Thyroid ultrasound
  • Fine needle aspiration (FNA) if scan features warrant

We arrange specialist referral for nodules requiring further evaluation.

How we assess at MHW

Our approach to thyroid testing

Many people are told their thyroid is "normal" after a single TSH test. That’s not always sufficient. A proper thyroid evaluation includes TSH, free T4, free T3, thyroid antibodies, and key co-factors (ferritin, vitamin D, B12) that affect both thyroid function and symptoms.

1. Detailed history

Symptoms, duration, family history of thyroid or autoimmune conditions, medications, recent pregnancy, prior treatments, neck symptoms.

2. Examination

Including neck examination for goitre or nodules, pulse, blood pressure, reflexes, skin and hair changes, weight.

3. Comprehensive blood testing

  • TSH
  • Free T4
  • Free T3
  • Anti-TPO antibodies
  • Anti-thyroglobulin antibodies
  • TSH receptor antibodies (if hyperthyroidism)
  • Reverse T3 (selected cases)
  • Ferritin, vitamin D, B12, folate (commonly contribute to fatigue symptoms)
  • HbA1c (where indicated)

4. Ultrasound if indicated

For palpable nodules, goitre, or other clinical findings.

5. Plan

Treatment, monitoring, or referral as appropriate.

Treatment

Hypothyroidism

The standard treatment is thyroid hormone replacement. Treatment is lifelong for most causes (autoimmune, post-surgical). NICE NG145 outlines current treatment principles:

  • Replacement is titrated to TSH (and sometimes T4) levels
  • Most patients require multiple dose adjustments over weeks-months to optimise
  • Goals are symptom resolution alongside biochemical normalisation
  • For patients who don’t feel well on standard treatment alone, other options exist and are discussed individually
  • Once stable, monitoring is typically annual

UK law prevents naming specific prescription medications on this website — specific options are discussed in clinic.

Hyperthyroidism

Treatment depends on cause and severity. Options include antithyroid medication, radioactive iodine, or surgery. We refer to endocrinology for hyperthyroidism management.

Subclinical disease

Treatment decisions in subclinical hypo- or hyperthyroidism depend on TSH level, antibody status, symptoms, age, and other factors. Not all subclinical disease is treated; some warrants monitoring only.

Pregnancy

Thyroid management during pregnancy is specialist territory — targets are different, doses often need adjustment, and outcomes (maternal and fetal) depend on good control. We refer to obstetric and endocrine teams as needed.

Long-term monitoring

Once stable, most patients need annual TSH/T4 review. We can perform this and adjust dosing as needed, or share care with your NHS GP. Common reasons dose may need adjustment:

  • Pregnancy (often need higher doses)
  • Significant weight change
  • Other medications (iron, calcium, others can affect absorption)
  • Ageing
  • Worsening of underlying disease (more thyroid tissue lost)

When to see us

Consider booking if:

  • You have symptoms suggestive of thyroid dysfunction
  • You’ve had a borderline thyroid result and want fuller evaluation
  • You’ve been told your thyroid is normal but feel unwell
  • You have a family history of thyroid or autoimmune disease and want screening
  • You’re on thyroid replacement but symptoms persist
  • You want a second opinion on thyroid management
  • You’ve found a lump in your neck
  • You’re post-pregnancy and feel unwell (postpartum thyroiditis is common)
  • You’re planning pregnancy and have a thyroid history

Frequently asked questions

My TSH is normal but I still feel awful — what could it be?

Several possibilities: subclinical thyroid issues at the upper normal range, conversion problems (T4 not converting to active T3), nutritional contributors, other conditions mimicking thyroid (iron deficiency, perimenopause, depression, sleep apnoea). A fuller assessment often clarifies.

Why does the NHS only test TSH?

For most patients with established disease on treatment, TSH is sufficient. For diagnostic workup or when patients aren’t feeling well despite normal TSH, fuller testing including T4, T3, and antibodies adds clinical value.

How much does the comprehensive panel cost?

Current prices are on our Fees page. We quote before testing.

What about T3-containing treatments?

NICE NG145 recommends a trial of T3 in patients with persistent symptoms despite optimised T4 alone. This requires careful supervision and isn’t suitable for everyone. We can discuss whether this fits your situation.

Are natural desiccated thyroid (NDT) preparations a good option?

NDT (e.g. some specific preparations) is used by some practitioners for hypothyroidism. NICE doesn’t routinely recommend it; some patients prefer it. We can discuss the evidence and considerations honestly in consultation.

I have Hashimoto’s antibodies but normal hormones — what now?

This is common. Positive antibodies indicate immune attack on the thyroid but doesn’t always mean immediate treatment. Annual monitoring is appropriate to detect when thyroid function starts to decline.

Will treatment make me lose weight?

If you’ve gained weight from untreated hypothyroidism, some weight loss is expected once treatment normalises metabolism. Thyroid medication isn’t a weight-loss treatment for people with normal thyroid function.

Can I have children with thyroid disease?

Yes, but it’s important to have thyroid optimised before conception and properly managed during pregnancy. We support pre-conception planning.

Will insurance cover this?

Most UK PMI policies cover thyroid investigation and management. We provide procedure codes.

Your care at MHW

Who oversees thyroid disease care at MHW

Care at MHW Clinic is delivered by a small clinical team, with Dr Haydar Bolat as Clinical Director. The specific clinicians involved in your care depend on the plan agreed with you at consultation.

Dr Haydar Bolat
Clinical Director · GP

Dr Haydar Bolat

UK-registered GP and Clinical Director at MHW. Conducts comprehensive thyroid assessments including history, examination, full thyroid blood panel interpretation, and individualised treatment. Refers to endocrinology where specialist input is needed.

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Languages spoken across the team: English, Turkish, Bulgarian, Bengali, Hindi, Albanian, Azerbaijani, German, Romanian. We can also arrange professional telephone interpreters in most other languages at no extra cost. More on languages and interpreters →

Editorial review

This page was reviewed by Dr Haydar Bolat, Clinical Director at MHW Clinic. Content is based on NICE Guideline NG145 (Thyroid disease: assessment and management), British Thyroid Association guidance, and current UK clinical practice and current UK clinical practice. It is updated when guidance changes. Educational information only — not a substitute for clinical assessment.

Get a proper thyroid assessment

Comprehensive panel, careful interpretation, individualised treatment. Book a consultation if you suspect thyroid issues.

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